Blackmores Brain Active contains Longvida, an optimised form of curcumin (the active ingredient in turmeric). Longvida[R] is based on over 10 years research by neuroscientists at University of California in Los Angeles (UCLA). It may support alertness and working memory (part of short-term memory) and may help reduce mental fatigue.
Back in the late 1990s, neuroscientists at UCLA embarked on a mission to fi nd natural compounds that had potential to support brain health. One of the ingredients they came across was turmeric and more importantly, its active constituent, curcumin. They saw that turmeric had an extensive history of use in humans, a low toxicity profile and possessed a diverse range of properties that were associated with general health and the brain, including anti-infl ammatory and antioxidant activity.
Bioavailability of curcumin
Unformulated (regular) curcumin has poor oral bioavailability in humans. Using advanced SLCP technology, Longvida[R] encases the curcumin particle inside an optimised matrix layer. This helps to "protect the curcumin from the harsh environment in the stomach and allows it to dissolve at the optimal point of absorption in the gastrointestinal tract", for superior bioavailability.
Curcumin in the brain
Curcumin possesses antioxidant activity and turmeric extracts/ powders are well known for their anti-infl ammatory activity. The brain contains a high percentage of neurons and fatty acids, including the omega-3 fatty acid DHA. DHA is susceptible to free radical damage. Although the mechanisms are not completely understood, excessive inflammation and oxidative stress both appear to impact the brain.
A 4-week trial in healthy older adults taking one capsule containing 400 mg Longvida[R] daily for 30 days helped to modify markers in the body associated with stress, antioxidant activity and brain health/ageing.