Diaformin XR 500mg Tablets 360 (3 x 120) NO LONGER STOCKER - SEE Metex XR 500mg


Temporarily Low Stock Online -
Please Try Your Local Store
Drug Name: metformin
Our Price $17.07
PBS $0.00
Concession $0.00
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Diaformin XR 500mg Tablets 360 (3 x 120) NO LONGER STOCKER - SEE Metex XR 500mg

Diaformin XR 500mg Tablets 360 (3 x 120) NO LONGER STOCKER - SEE Metex XR 500mg

Product ID: 61465
Temporarily Low Stock Online
This Product Is Currently Available
In Store Only

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet
This leaflet answers some common questions about Diaformin XR.

It does not contain all the available information. It does not take the place of talking to your doctor, pharmacist or diabetes educator.

All medicines have benefits and risks. Your doctor has weighed the risks of you taking Diaformin XR against the benefits expected for you.

If you have any concerns about taking this medicine, talk to your doctor, pharmacist or diabetes educator.

Keep this leaflet with your medicine. You may need to read it again.

What Diaformin XR is used for
Diaformin XR is used to control blood glucose (sugar) in people with Type 2 diabetes mellitus, especially in those who are overweight. It is used when diet and exercise are not enough to control high levels of blood glucose.

Diaformin XR can be used alone, or in combination with other medicines for treating diabetes.


Type 2 diabetes mellitus is also called non-insulin dependent diabetes mellitus (NIDDM) or maturity onset diabetes.

Insulin is a hormone that enables body tissues to take up glucose from the blood and to use it for energy or fat storage for future use.

People with Type 2 diabetes are unable to make enough insulin or their body does not respond properly to the insulin it does make. This causes a build up of glucose in the blood (hyperglycaemia), which can lead to serious medical problems.

Long-term hyperglycaemia can lead to heart disease, blindness, kidney damage, poor blood circulation and gangrene.

Signs of hyperglycaemia may include:

tiredness or lack of energy
passing large amounts of urine
blurred vision.
How Diaformin XR works
Diaformin XR belongs to a group of medicines called biguanides. It lowers high blood glucose levels by:

improving your body's sensitivity to insulin and restoring the way it normally uses glucose
reducing the amount of glucose your liver makes
delaying the amount of glucose your intestine absorbs
Ask your doctor if you have any questions about why Diaformin XR has been prescribed for you.

Diaformin XR is not recommended in children as its safety and effectiveness have not been established in this age group.

Diaformin XR is available only with a doctor's prescription.

There is no evidence that Diaformin XR is addictive.

After the active ingredient metformin is absorbed into your body, you may see the empty tablet shell in your faeces (bowel motions). This is normal and does not affect the way Diaformin XR works.

Before you take Diaformin XR
When you must not take it
Do not take Diaformin XR if you are allergic to:

medicines containing metformin or any other biguanide
any of the ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing, wheezing or shortness of breath.

Do not take Diaformin XR if you have any of the following medical conditions:

type 1 diabetes mellitus that is well controlled by insulin alone
type 2 diabetes that is already well controlled by diet alone
serious complications with your diabetes or diabetic ketoacidosis (a symptom of uncontrolled diabetes, in which substances called ketone bodies accumulate in the blood - you may notice this as an unusual fruity odour on your breath)
kidney failure or severe kidney disease
dehydration(for instance due to persistent or severe vomiting or diarrhoea)
shock from severe injury or blood loss
severe liver disease
acute alcohol intoxication, chronic alcohol dependence
certain heart or blood circulation problems, including a recent heart attack or heart failure (when the heart fails to pump blood effectively)
blood clots in the lungs (symptoms include coughing, shortness of breath, chest pain and a fast heart rate), severe breathing difficulties
inflammation of the pancreas (symptoms include severe upper stomach pain, often with nausea and vomiting) if associated with severe infection or hypoxia (lack of oxygen)
a severe infection or gangrene.
Do not take Diaformin XR if you need to have major surgery or an examination such as an X-ray or a scan requiring an injection of iodinated contrast (dye). You must stop taking Diaformin XR for a certain period of time before and after the examination or the surgery. Your doctor will decide whether you need any other treatment for this time. It is important that you follow your doctor's instructions precisely.

Do not take this medicine if you are pregnant or plan to become pregnant. Insulin is more suitable for controlling blood glucose during pregnancy. Your doctor will replace Diaformin XR with insulin while you are pregnant.

Do not take Diaformin XR if you are breastfeeding. Your doctor will discuss the options available to you.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering. If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking Diaformin XR, ask your doctor.

Before you start to take it
Tell your doctor if you have allergies to any other medicines, foods, dyes or preservatives.

Before starting Diaformin XR your doctor will ask you to have a blood test to check your kidney function.

Tell your doctor if you have or have had any of the following medical conditions:

kidney problems
liver problems
heart or blood vessel problems including heart failure.
Tell your doctor if you drink alcohol. Alcohol can affect the control of your diabetes. Drinking excessive amounts of alcohol while you are being treated with Diaformin XR may also lead to serious side effects. Your doctor may suggest you stop drinking or reduce the amount of alcohol you drink.

If you have not told your doctor about any of the above, tell him/her before you start taking Diaformin XR.

Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from a pharmacy, supermarket or health food shop.

Some medicines and Diaformin XR may interfere with each other. These include:

other medicines used to treat diabetes
iodinated contrast agents (dyes)
medicines that contain alcohol, such as cough and cold syrups
corticosteroids such as prednisone or cortisone
tetracosactrin, a medicine used in people with multiple sclerosis, and in young children to treat some types of seizures (fits)
danazol, a medicine used to treat endometriosis
medicines used to treat high blood pressure and some heart conditions, such as beta-blockers, calcium channel blockers or ACE inhibitors
some medicines used to treat asthma such as salbutamol or terbutaline
diuretics, also called fluid tablets
chlorpromazine, a medicine used to treat schizophrenia and other mental illnesses
NSAIDs (non-steroidal anti-inflammatory drugs), medicines used to relieve pain, swelling and other symptoms of inflammation, such as aspirin, diclofenac, ibuprofen, meloxicam, naproxen or piroxicam
cimetidine, used to treat ulcers and reflux
medicines used to prevent blood clots such as warfarin.
These medicines may be affected by Diaformin XR or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.

Your doctor and pharmacist also have more information on medicines to be careful with or avoid while taking Diaformin XR.

How to take Diaformin XR
Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your doctor or pharmacist.

How much to take
The dose varies from patient to patient. Your doctor will decide the right dose for you.

The usual starting dose is 1 tablet (500 mg) once daily with the evening meal. Your doctor may increase the dose slowly, depending on your blood glucose levels.

The maximum recommended dose is 4 tablets (2 grams) once per day.

Elderly patients and people with kidney problems may need smaller doses.

How to take it
Swallow the tablets whole with a glass of water.

Do not break, crush or chew the tablets. If you break, crush or chew Diaformin XR, they will not work as well. Diaformin XR are extended release tablets. This means they have a special coating which allows the active ingredient, metformin, to be released slowly over time.

When to take it
Take your medicine everyday with the evening meal. Taking Diaformin XR during or with your evening meal will reduce the chance of a stomach upset.

Taking it at the same time each day will have the best effect. It will also help you remember when to take it.

How long to take it for
Keep taking Diaformin XR for as long as your doctor recommends. Diaformin XR will help control diabetes but will not cure it. Most people will need to take Diaformin XR for long periods of time.

When you start treatment with Diaformin XR, it can take up to some weeks for your blood glucose levels to be properly controlled.

If you forget to take it
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally.

Do not take a double dose to make up for the dose you missed.

If you are not sure what to do, ask your doctor or pharmacist.

If you take too much (overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Diaformin XR. Do this even if there are no signs of discomfort or poisoning.

If you take too much Diaformin XR, you may feel very tired, sick, vomit, have trouble breathing and have unusual muscle pain, stomach pain or diarrhoea. These may be early signs of a serious condition called lactic acidosis (build up of lactic acid in the blood).

You may also experience symptoms of hypoglycaemia (low blood glucose). This usually only happens if you take too much Diaformin XR together with other medicines for diabetes or with alcohol.

If you do experience any signs of hypoglycaemia, raise your blood glucose quickly by eating jelly beans, sugar or honey, drinking non-diet soft drink or taking glucose tablets.

While you are taking Diaformin XR
Things you must do
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Diaformin XR.

Tell all the other doctors, dentists and pharmacists who treat you that you are taking this medicine.

If you become pregnant while taking this medicine, tell your doctor immediately.

Diaformin XR does not normally cause hypoglycaemia (low blood sugar), although you may experience it while taking other medicines for diabetes such as insulin or sulfonylureas.

Make sure that you, your friends, family and work colleagues can recognise the symptoms of hypoglycaemia (low blood sugar) and know how to treat them.

Hypoglycaemia can occur suddenly. Initial signs may include:

weakness, trembling or shaking
lightheadedness, dizziness, headache or lack of concentration
irritability, tearfulness or crying
numbness around the lips and tongue.
If not treated promptly, these may progress to:

loss of co-ordination
slurred speech
fits or loss of consciousness.
If you experience any of the symptoms of hypoglycaemia, you need to raise your blood glucose immediately.

You can do this by doing one of the following:

eating 5 to 7 jelly beans
eating 3 teaspoons of sugar or honey
drinking half a can of non-diet soft drink
taking 2 to 3 concentrated glucose tablets.
Unless you are within 10 to 15 minutes of your next meal or snack, follow up with extra carbohydrates such as plain biscuits, fruit or milk.

Taking this extra carbohydrate will prevent a second drop in your blood glucose level.


If you experience any of the signs of hyperglycaemia (high blood sugar), contact your doctor immediately.

The risk of hyperglycaemia is increased in the following situations:

uncontrolled diabetes
illness, infection or stress
taking less Diaformin XR than prescribed
taking certain other medicines
too little exercise
eating more carbohydrates than normal.
Tell your doctor if any of the following happen:

you become ill
you become dehydrated (for instance due to persistent or severe diarrhoea or recurrent vomiting)
you are injured
you have a fever
you have a serious infection such an influenza, respiratory tract infection or urinary tract infection
you are having major surgery
you are having an examination such as an X-ray or a scan requiring an injection of an iodinated contrast agent (dye).
Your blood glucose may become difficult to control at these times. You may also be more at risk of developing a serious condition called lactic acidosis. At these times, your doctor may replace Diaformin XR with insulin.

Visit your doctor regularly for check ups. Your doctor may want to check your kidneys, liver, heart and vitamin B12 levels while you are taking Diaformin XR.

Check your blood glucose levels regularly. This is the best way to tell if your diabetes is being controlled properly. Your doctor or diabetes educator will show you how and when to do this.

Carefully follow the advice of your doctor and dietician on diet, drinking alcohol and exercise.

Things you must not do
Do not use Diaformin XR to treat any other complaints unless your doctor tells you to.

Do not give your medicine to anyone else, even if they have the same condition as you.

Do not skip meals while taking Diaformin XR.

Do not stop taking your medicine or change the dosage without checking with your doctor.

Things to be careful of
If you have to be alert, for example when driving, be especially careful not to let your blood glucose levels fall too low. Low blood glucose levels may slow your reaction time and affect your ability to drive or operate machinery. Drinking alcohol can make this worse. However, Diaformin XR by itself is unlikely to affect how you drive or operate machinery.

Side effects
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Diaformin XR. Diaformin XR helps most people with diabetes but it may have unwanted side effects in some people.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by the following lists of side effects. You may not experience any of them.

Tell your doctor if you notice any of the following and they worry you:

feeling sick (nausea)
stomach pain
taste disturbance
loss of appetite
skin reactions such as redness of the skin, itching or an itchy rash (urticaria).
These are generally mild side effects which disappear after the first few weeks. Taking Diaformin XR with meals can help reduce nausea and diarrhoea.

Tell your doctor as soon as possible if you notice any of the following:

symptoms of liver disease such as nausea, vomiting, loss of appetite, feeling generally unwell, fever, yellowing of the skin and eyes and dark coloured urine

nausea, vomiting, stomach pain
trouble breathing
feeling weak, tired or generally unwell
unusual muscle pain
dizziness or lightheadedness
shivering, feeling extremely cold
slow heart beat.

Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

Other side effects not listed above may also occur in some people. Some side effects (e.g. reduced vitamin B12 level) can only be found when your doctor does tests from time to time to check your progress.

After using Diaformin XR
Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep your tablets in a cool, dry place where the temperature stays below 25 degrees C.

Do not store Diaformin XR or any other medicine in the bathroom or near a sink. Do not leave it in the car or on a window sill. Heat and dampness can destroy some medicines.

Keep Diaformin XR where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.

Product description
What it looks like
Diaformin XR is a white to off-white, capsule-shaped tablet, marked "500" on one side. It is available in blister packs of 90 and 120 tablets.

The active ingredient in Diaformin XR is metformin hydrochloride.

Each extended release tablet contains 500 mg of metformin hydrochloride.

The tablets also contain the following inactive ingredients:

croscarmellose sodium
microcrystalline cellulose
magnesium stearate.
The tablets do not contain sucrose, lactose, gluten, tartrazine or any other azo dyes.

Diaformin XR is supplied in Australia by:
Alphapharm Pty Limited
(ABN 93 002 359 739)
Chase Building 2
Wentworth Park Road
Glebe NSW 2037
Phone: (02) 9298 3999

Medical Information
Phone: 1800 028 365

Australian registration numbers:
Diaformin XR - AUST R 120868

This leaflet was prepared on
5 May 2009.

* Registered trade mark of Alphapharm Pty Limited.
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