Avandamet 4mg/500mg Tablets 56


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Drug Name: rosiglitazone + metformin
Private Price $91.39
PBS $37.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Avandamet 4mg/500mg Tablets 56

Avandamet 4mg/500mg Tablets 56

Product ID: 55676
Temporarily Low Stock Online
Temporarily Low Stock Online -
Please Try Your Local Store

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet?

Please read this leaflet carefully before you take AVANDAMET. If you are helping someone else to take AVANDAMET, please read this leaflet carefully before you give the first dose.

This leaflet answers some common questions about AVANDAMET. It does not contain all of the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Sometimes new risks are found even when a medicine has been used for many years. Your doctor has weighed the expected benefits of you taking AVANDAMET against the risks this medicine could have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.

What is AVANDAMET used for?

AVANDAMET is used to treat patients with type 2 diabetes mellitus. This is also called non-insulin dependent diabetes (NIDDM) or maturity onset diabetes.

Type 2 diabetes mellitus is a condition in which your body does not make enough insulin or where the insulin that your body produces does not work as well as it should. Insulin is a natural body chemical that helps the body's cells use the sugar from the blood and so stops your blood sugar levels from rising too high. High blood sugar levels can cause damage to the body's cells.

AVANDAMET contains two active ingredients; namely rosiglitazone (as maleate), which belongs to a group of medicines called glitazones, and metformin hydrochloride which belongs to a group of medicines called biguanides.

AVANDAMET acts by making your body more sensitive to insulin. It therefore helps your body make better use of the insulin it produces and thus helps to restore your blood sugar towards a normal level.

Your doctor may have prescribed AVANDAMET for another reason.

There is no evidence that AVANDAMET is addictive.

Before you take AVANDAMET

Do not take if:

You must not take AVANDAMET if:
you have heart failure or have had heart failure in the past.
You are being treated for angina or having a heart attack.
you have ever had an allergic reaction to rosiglitazone or metformin or any of the ingredients listed toward the end of this leaflet. (See "Ingredients") Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue.
the expiry date (EXP) printed on the pack has passed.
the packaging is torn or shows signs of tampering

Tell your doctor if:

You must tell your doctor if:
you are breastfeeding, pregnant or trying to become pregnant.
you have heart failure or have had heart failure in the past.
you have breathing difficulties
you have a history of swelling or pain of legs and feet
you have a problem with your liver. The medicine may remain in your body longer than usual.
you have visual disorders
you are taking insulin
you are taking nitrates for existing heart disease because heart problems such as angina and heart attack have been reported.
you are taking other anti-diabetic medications.
you have polycystic ovary syndrome. Due to the way your medicine works there may be an increased risk of pregnancy.
you are allergic to foods, dyes, preservatives or any other medicines.
you are taking any other medicines, including medicines you buy without a prescription.

Broken bones, usually in the hand, upper arm or foot, have been seen with rosiglitazone use in women. Talk to your doctor for advice on how to keep your bones healthy.

AVANDAMET only works in the presence of the body's own insulin therefore it should not be used in patients with type 1 (or insulin dependent) diabetes mellitus.

There is no information available on the use of AVANDAMET in people under 18 years of age, therefore its use in these patients is not recommended.

How do I take AVANDAMET?

How much to take:

Take AVANDAMET as directed by your doctor or pharmacist. The amount of AVANDAMET people take can be different, and this depends on your condition. Your doctor will prescribe the best dose for you.

Do not take more tablets than your doctor has recommended.

How to take it:

Your AVANDAMET tablets should be swallowed with a glass of water. They may be taken with or after a meal or on an empty stomach. It is best to take the tablets at the same time each day.

How long to take it for:

Diabetes is a condition that requires long term treatment and regular assessment by your doctor. Once you have started taking medication, you will normally need to keep taking it for the rest of your life.

If you feel the effect of your medicine is too weak or too strong do not stop taking AVANDAMET or change the dose yourself, but ask your doctor.

Your doctor may prescribe AVANDAMET in combination with other anti-diabetic medicines. Read the leaflets for these medicines too.

Use in children:

There is no information available on the use of AVANDAMET in people under 18 years of age, therefore its use in these patients is not recommended.

What do I do if I take too much? (Overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 131126) for advice, if you think you or anyone else may have taken too much AVANDAMET, even if there are no signs of discomfort or poisoning.

If you are not sure what to do, contact your doctor, pharmacist or nearest hospital.

While you are taking AVANDAMET

Things you must do:

Tell your doctor if, for any reason, you have not taken your medicine exactly as directed. Otherwise, your doctor may think that it was not working as it should and change your treatment unnecessarily.

If you forget to take AVANDAMET, take your tablet as soon as you remember. Do not take any more than the usual dose. Take your next dose at the usual time.

Things you must not do:

Do not give this medicine to anyone else, even if their symptoms seem similar to yours.

Do not use AVANDAMET to treat any other complaints unless your doctor says to.

Do not skip meals while taking AVANDAMET.

Do not stop taking AVANDAMET or change the dose without checking with your doctor first.

Things to be careful of:

Be careful driving or operating machinery until you know how AVANDAMET affects you.

If you have to be alert, for example when driving, be especially careful not to let your blood glucose levels fall too low.

What are the side-effects?

Check with your doctor as soon as possible if you think you are experiencing any side effects or allergic reactions due to taking AVANDAMET, even if the problem is not listed below.

AVANDAMET may increase the risk of heat attack or heart failure in some patients. You must tell your doctor immediately if you develop any of the following:
rapid increase in weight
shortness of breath
swelling of legs and feet
chest pain

Like other medicines, AVANDAMET can cause some side-effects. If they occur, they are most likely to be minor and temporary. However, some may be serious and need medical attention.

The most commonly reported side-effects are:
heart failure or fluid in the lungs (pulmonary oedema).
heart problems such as angina or heart attack
localised swelling (oedema)
a small increase in weight
low sugar levels in the blood (hypoglycaemia).
a small reduction in red blood cell count (anaemia) and white blood cell count
broken bones, usually in the hand, upper arm or foot.

Tell your doctor immediately if you notice any of the following:
stomach upset such as nausea or vomiting
chest pain
itching, rash
dark urine or pale stools
yellowing of the skin or eyes (jaundice)
severe stomach cramps
loss of weight
shortness of breath
swelling or pain of legs and feet
rapid increase in weight
visual disorders
Wheezing, swelling of the lips/mouth, difficulty in breathing, hayfever, lumpy rash (hives) or fainting. These could be symptoms of an allergic reaction.

Tell your doctor immediately or go to the Emergency Department at the nearest hospital if you notice any of the following symptoms of lactic acidosis (high lactic acid in the blood).
nausea, vomiting, stomach pain.
difficulty in breathing.
feeling weak, tired or generally unwell.
unusual muscle pain.
dizziness or light-headedness.
shivering, feeling extremely cold.
slow heart beat.

You may need urgent medical attention. Lactic acidosis with AVANDAMET is rare. The risk of lactic acidosis is higher in some patients, including the elderly, those taking doses of metformin greater than 2 g per day, those drinking excessive amounts of alcohol and those whose kidneys are not working properly.

This is not a complete list of all possible side-effects. Others may occur in some people and there may be some side-effects not yet known.

Tell your doctor or pharmacist if you notice any side effects from your medicine which are not mentioned here.

Do not be alarmed by this list of possible side-effects. You may not experience any of them.

How do I store AVANDAMET?

AVANDAMET tablets should be stored in a cool, dry place below 30 °C.

Keep this medicine where children cannot reach it, such as in a locked cupboard.

Do not leave in a car, on a window sill or in the bathroom.

Keep AVANDAMET in its blister pack until time to take.

Return any unused or expired medicine to your pharmacist.

Product description

What AVANDAMET looks like:

AVANDAMET tablets are film-coated oval tablets, debossed with 'gsk' on one side, and the following debossing on the reverse side. The tablets are also distinguished by colour.

'2/500' - 2 mg rosiglitazone/500 mg metformin hydrochloride pale pink tablet

'4/500' - 4 mg rosiglitazone/500 mg metformin hydrochloride orange tablet

'2/1000' - 2 mg rosiglitazone/1000 mg metformin hydrochloride yellow tablet

'4/1000' - 4 mg rosiglitazone/1000 mg metformin hydrochloride pink tablet


AVANDAMET contains the active ingredients rosiglitazone (as maleate) and metformin hydrochloride.

AVANDAMET also contains sodium starch glycollate, hypromellose, microcrystalline cellulose, povidone, magnesium stearate, titanium dioxide, macrogol 400, iron oxide yellow and iron oxide red.

Patients who are intolerant to lactose should note that each AVANDAMET tablet also contains a small amount of lactose.


Your AVANDAMET is supplied by:
GlaxoSmithKline Australia Pty Ltd
1061 Mountain Highway
Boronia, Victoria, 3155

Where to go for further information:

Pharmaceutical companies are not in a position to give people an individual diagnosis or medical advice. Your doctor or pharmacist is the best person to give you advice on the treatment of your condition. You may also be able to find general information about your disease and its treatment from patient information groups and product specific organisations eg. Diabetes Australia.

This leaflet was prepared on 19 August 2008

The information provided applies only to: AVANDAMET®.
® AVANDAMET is a registered trademark of the GlaxoSmithKline Group of Companies.
2mg/500mg - AUST R 114516
4mg/500mg - AUST R 114517
2mg/1000mg - AUST R 115430
4mg/1000mg - AUST R 115459

This leaflet is subject to copyright.

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