Pyralin EN 500mg Tablets 200 (2 x 100)


Drug Name: sulfasalazine
Private Price $50.78
PBS $37.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Pyralin EN 500mg Tablets 200 (2 x 100)

Pyralin EN 500mg Tablets 200 (2 x 100)

Product ID: 53487

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet

Please read this leaflet carefully before you start taking Pyralin EN. This leaflet answers some common questions about Pyralin EN. It does not contain all the available information and does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your Doctor has weighed the risks of you taking Pyralin EN against the benefits this medicine is expected to have for you.

Use Pyralin EN as instructed and follow the advice given in this leaflet.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with your medicine. You may need to read it again.

What Pyralin EN is used for

Pyralin EN belongs to a group of medicines called anti-inflammatory medicines and is used to treat and manage Ulcerative Colitis and Crohn's disease which are diseases of the bowel.

Pyralin EN is also used to treat rheumatoid arthritis which is a painful joint disease.

This medicine is available only with a doctor's prescription.

There is no evidence that Pyralin EN is addictive.

Before you take Pyralin EN

Some information is provided below. However, always talk to your doctor if you have concerns or questions about your treatment.

When you must not take Pyralin EN

Do not take Pyralin EN if you have an allergy to:
sulfur-containing medicines eg. sulfonamides; some oral hypoglycaemics (diabetes medicine) eg. glipizide; thiazide diuretics eg. chorothiazide
salicylates eg. aspirin
any of the ingredients of Pyralin EN which are listed under the heading, "Product Description", at the end of this leaflet.

Symptoms of an allergic reaction to Pyralin EN may include skin rash and itching, breathlessness and anaphylactic reactions (major allergic reactions).

If you are not sure if you have or have had an allergic reaction to Pyralin EN, check with your doctor.

Do not take Pyralin EN if:
you have kidney or liver problems
you have any form of blood disorder
you have any form of intestinal or urinary obstruction.
you have porphyria (rare disease of blood pigments)

If you are not sure about any of the above, ask your doctor.
the packaging is torn or shows signs of tampering or the tablets do not look quite right.
the expiry date (Exp.) on the carton has passed.

If you take this medicine after the expiry date has passed, it may not work as well.

Do not give Pyralin EN to children under two years of age.

Do not use Pyralin EN to treat any other complaints unless your doctor says to.

Do not give this medicine to anyone else.

See your Doctor for a check up before you start to take Pyralin EN.

Before you start to take Pyralin EN.

Tell your doctor if you:
are pregnant or trying to become pregnant.
are breast feeding or plan to breast-feed.

Your doctor will discuss the possible risks and benefits of taking Pyralin EN during pregnancy and breast-feeding.
are allergic to any other medicines or any other substances such as foods, preservatives or dyes
have a glucose-6-phosphate dehydrogenase (G-6-P) deficiency. This is a rare blood disorder which means that your body cannot get rid of some medicines.
have bronchial asthma (wheezing or shortness of breath)

Taking other medicines

Tell your Doctor if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop.

There may be interference between Pyralin EN and some other medicines including:
oral medicines used to prevent blood clots eg. warfarin
methotrexate, a medicine used to treat arthritis and some cancers
medicines to lower blood sugar or control diabetes
mercaptopurine and azathioprine, medicines used to treat some cancers
antacids, medicines that help to control heartburn or symptoms of indigestion
digoxin, a medicine used to treat heart failure
oxyphenbutazone, phenylbutazone, indomethacin and sulfinpyrazone which are medicines used to treat arthritis and gout
oxacillin and penicillins, which are types of antibiotics
certain local anaesthetics
medicines used to make the urine more acidic
iron tablets

These medicines may be affected by Pyralin EN or may affect how well it works. You may need different amounts of your medicine or you may need to take different medicines. Your doctor or pharmacist has more information on medicines to be careful with or to avoid while taking Pyralin EN.

How to take Pyralin EN

How to take it

Your doctor will tell you how to take your Pyralin EN tablets. The directions your doctor gives you should be strictly followed. The directions given to you by your doctor may differ from the information contained in this leaflet. You may be given a different dosage depending on your condition and how you react to this medicine.

Pyralin EN should be swallowed after meals with water.

It is important to maintain adequate fluid intake while taking Pyralin EN.

Do not crush,break or chew these enteric-coated tablets.

How much to take and when to take it

Inflammatory Bowel Disease

Pyralin EN should be taken after meals in evenly spaced doses over each 24 hour period.

Adults: The usual initial dose is 2 to 4 tablets, four times a day.

The usual maintenance dose is 4 tablets a day.

Children: Your doctor will determine the proper dose, taking into account the age and weight of the child.

Rheumatoid Arthritis

Adults: The usual dose is 2 tablets, two to three times a day.

It is usual to start taking Pyralin EN at a lower dose and gradually increase. Your doctor will advise whether you should do this and how to do this.

At present there is no dose recommendation for treating rheumatoid arthritis in children.

How long to take it

Continue taking Pyralin EN for as long as your doctor recommends. If you forget to take it

If you forget to take your Pyralin EN take your next dose at the normal time it is due.

Do not try to make up for missed doses by taking more than one dose at a time because this may increase the chance of you getting an unwanted side effect.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at your nearest hospital if you think you or anyone else may have taken too much Pyralin EN. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Keep telephone numbers for these places/services handy. Have the Pyralin EN bottle or this leaflet available to give details if needed.

The symptoms of taking too many Pyralin EN tablets may include stomach discomfort and other effects listed under the heading "Side effects" in this leaflet.

While you are taking Pyralin EN

Things you must do

Advise your doctor immediately if you notice any unusual symptoms. Ensure you drink plenty of fluids while on Pyralin EN. Tell your doctor if you become pregnant while taking Pyralin EN. If you are about to start taking any new medicines, tell your doctor or pharmacist that you are taking Pyralin EN. Tell all doctors, dentists and pharmacists who are treating you that you are taking Pyralin EN. Ensure that you keep all doctor's appointments for check-ups and any tests that your doctor may order for you while you are taking Pyralin EN. Protect your skin when you are in the sun, especially between 10am and 3pm. Pyralin EN may cause your skin to be more sensitive to sunlight than it is normally. If outdoors, wear protective clothing and use a 15+ sunscreen. If your skin does appear to be burning, tell your doctor immediately. Exposure to sunlight may cause a skin rash, itching, redness or a severe sunburn. Things you must not do

Do not stop taking Pyralin EN or change the dose without first checking with your doctor.

Do not give Pyralin EN to anyone else even if they have the same condition as you.

Side Effects

Check with your doctor as soon as possible if you have any concerns while taking Pyralin EN, even if you do not think the concerns are connected with the medicine or are not listed in this leaflet.

All medicines can have side effects and Pyralin EN may have unwanted side effects in a few people. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:
nausea and vomiting
loss of appetite
raised temperature
redness and itchiness of the skin
stomach pains
swelling of the liver
abnormal change in sense of smell or taste
ringing in the ears
yellow skin
allergic reactions
skin rash
loss of hair
increased sensitivity to light

If these effects do not go away or they are worrying to you, tell your doctor.

If you get a sore throat, fever, pallor, rash and yellow skin tell your doctor immediately. This may mean that you have a serious blood disorder and need urgent medical care.

Pyralin EN can also cause:

blood cell changes, low sperm count (which is reversible), pancreatitis (swelling of the pancreas), stomatitis (swelling in the mouth), impaired folic acid absorption, peripheral neuropathy and neuritis (which cause tingling, burning or numbness in the hands or feet), kidney changes and lung complications. This is not a complete list of all possible side effects. Some people may get other side-effects while taking Pyralin EN. It is very important to tell your doctor immediately if you notice any side-effects while taking Pyralin EN. After treatment with Pyralin EN Storage

Keep your tablets where children cannot reach them Your Pyralin EN tablets should be stored in their original container in a cool, dry place where the temperature stays below 25 °C. If you take your tablets out of their bottle, they may not keep as well.

Make sure the container is well closed after use.

Do not store Pyralin EN or any other medicine in a bathroom or near a sink. Do not leave them in the car or on window sills. Heat and dampness can destroy medicines.


If your doctor tells you to stop taking Pyralin EN, or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets left over.

Product Description

What it looks like

Pyralin EN tablets are enteric coated 500mg tablets. They are yellow, oval, and marked with '102' on one side and 'KPh' on the other side.

Pyralin EN 500mg tablets come in plastic bottles containing 100 tablets.


Pyralin EN tablets can be identified by an Australian Register number which is found on the bottle label:

500 mg EN tablets: AUST R 58398 Ingredients

The active ingredient in each tablet is sulfasalazine. Each tablet contains 500mg sulfasalazine.

Pyralin EN tablets also contain: silica, magnesium stearate, maize starch, cellacephate, propylene glycol, white beeswax, carnauba wax, glyceryl monostearate, macrogol 20000 and talc.

Pyralin EN tablets do not contain lactose, sucrose, or tartrazine.


Pyralin EN is supplied in Australia by:-

Pfizer Australia Pty Ltd
ABN 50 008 422 348
38-42 Wharf Road
West Ryde NSW 2114

Toll Free Number: 1800 675 229

This leaflet was revised in March 2006.

© Pfizer Australia Pty Ltd

® Registered trademark

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