Toprol XL 190mg CR Tablets 30


Private Price $75.99
PBS $37.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Toprol XL 190mg CR Tablets 30

Toprol XL 190mg CR Tablets 30

Product ID: 47946

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet

This leaflet answers some of the common questions people ask about TOPROL-XL TABLETS. It does not contain all the information that is known about TOPROL-XL.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits. Your doctor will have weighed the risks of you taking TOPROL-XL against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.

What TOPROL-XL is for

TOPROL-XL belongs to a group of medicines called beta-blockers.

It works by affecting the body's response to some nerve impulses, especially in the heart. As a result, it decreases the heart's need for blood and oxygen and therefore reduces the amount of work the heart has to do. It also helps the heart to beat more regularly.

TOPROL-XL tablets are used to treat heart failure - increase survival, reduce hospitalisation and improve symptoms. It is used in combination with other medicines to treat your condition.

Your doctor may have prescribed this medicine for another reason.

Your doctor will have explained why you are being treated with

TOPROL-XL and told you what dose to take. Follow all directions given to you by your doctor carefully.

They may differ from the information contained in this leaflet.

Ask your doctor if you have any questions about why TOPROL-XL has been prescribed for you.

TOPROL-XL is not addictive.

Before you take TOPROL-XL

When you must not take it

Do not take TOPROL-XL tablets if:
1. you have or have had asthma (difficulty in breathing, wheezing and coughing), bronchitis or other lung problems in the past.
2. you have the following conditions:
a history of allergic problems, including hayfever
a very slow heart beat
a severe blood vessel disorder causing poor circulation in the arms and legs
certain other heart conditions
phaeochromocytoma (a rare tumour of the adrenal gland) which is not being treated with other medicines
low blood pressure (hypotension)
3. you are pregnant or intend to become pregnant

TOPROL-XL may affect your baby if you are given it early in pregnancy or in the last weeks before your baby is due.
4. you are breast-feeding or plan to breast-feed

TOPROL-XL passes into breast milk and therefore there is a possibility that the breast-fed baby may be affected.

Do not use TOPROL-XL if the expiry date (EXP) printed on the pack has passed. It may have no effect at all, or worse, an entirely unexpected effect if it is used after the expiry date.

Do not use TOPROL-XL if the packaging is torn or shows signs of tampering.

Do not give TOPROL-XL to children. The safety and effectiveness of TOPROL-XL in children has not been established.

Before you start to take it

You must tell your doctor if:
1. you have any allergies to
TOPROL-XL or any of the ingredients listed at the end of this leaflet
any other medicine or other beta-blocker medicines
any other substances, such as foods, preservatives or dyes
2. you have any of these medical conditions
asthma or other lung problems, even if you have had them in the past
allergic problems, including hayfever
very slow heart beat (less than 45-50 beats/minute)
severe blood vessel disorder causing poor circulation in the arms and legs
liver problems
kidney problems
certain types of angina
any other heart problems
hyperthyroidism (an overactive thyroid gland)

Tell you doctor if you plan to have surgery.

If you have not told your doctor about any of these things, tell them before you take TOPROL-XL.

Taking other medicines

Tell your doctor if you are taking any other medicines, including
other beta-blocker medicines, including beta-blocker eye drops
medicines used to treat high blood pressure or angina
medicines used to treat heart problems
insulin and tablets used to treat diabetes
medicines used to treat bacterial infections (e.g. rifampicin, quinidine)
anti-ulcer drugs (e.g. cimetidine)
anti-inflammatory drugs
medicines used to treat depression
monoamine-oxidase inhibitors (MAOIs)
medicines that you buy without a prescription at the chemist, supermarket or health food shop

These medicines may be affected by TOPROL-XL or may affect how well it works. You may need to take different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking TOPROL-XL.

If you have not told your doctor about any of these things, tell them before you take any TOPROL-XL.


How much to take

The usual starting dose is half a 23.75 mg or a whole 23.75 mg tablet once a day for one to two weeks. The dose is then usually doubled every second week up to a maximum dose of 190 mg once daily or to the highest tolerated dose.

TOPROL-XL tablets may be broken in half or swallowed whole with a glass of water as directed by your doctor. TOPROL-XL tablets should not be chewed or crushed.

Your doctor may tell you to take a different amount of TOPROL-XL.

Follow your doctor's instructions carefully.

If you are taking other medicines your doctor may need to change the dose of them to obtain the best results for you.


The dose needs to be reduced slowly over at least 14 days to make sure your condition does not get worse. Your doctor will tell you how to reduce the dose.

If you forget to take it

If you miss a dose of TOPROL-XL and your next dose is more than 12 hours away, take the missed dose right away.

If your next dose is less than 12 hours away take only half the dose.

Take your next dose when you are meant to.

Do not take a double dose to make up for the dose that you missed. If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.


Telephone your doctor, the Poisons Information Centre (13 11 26) or go to casualty at your nearest hospital immediately if you think that you or anyone else may have taken too much

TOPROL-XL. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. If you take too many TOPROL-XL tablets your blood pressure may drop too far. You will feel faint or may faint, and your heart rate will also slow down. You may also have nausea, vomiting and shortness of breath. In extreme cases, serious heart and lung problems may occur. While you are using TOPROL-XL Things you must do

Be sure to keep all of your doctor's appointments so that your progress can be checked.

If you become pregnant while taking TOPROL-XL, tell your doctor.

If you have a severe allergic reaction to foods, medicines or insect stings, tell your doctor immediately.

If you have a history of allergies, there is a chance that TOPROL-XL may cause allergic reactions to be worse and harder to treat.

If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly. You may feel light-headed or dizzy when you begin to take TOPROL-XL. This is because your blood pressure has fallen suddenly.

Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem gets worse or continues, talk to your doctor.

If you feel a worsening of your condition in the early stages of taking TOPROL-XL Some people may experience an apparent worsening of their condition in the early stages of treatment with TOPROL-XL. It is important to tell your doctor if this happens to you, although it is usually temporary. If your condition continues to worsen, you should see your doctor as soon as possible.

Make sure you drink enough water during exercise and hot weather when you are taking TOPROL-XL, especially if you sweat a lot. If you do not drink enough water while taking TOPROL-XL, you may feel faint or light-headed or sick. This is because your blood pressure is dropping too much. If you continue to feel unwell, tell your doctor.

If you plan to have surgery (even at the dentist) that needs a general anaesthetic, tell your doctor or dentist that you are taking TOPROL-XL. Your blood pressure may drop suddenly if TOPROL-XL interacts with the anaesthetic.

If you are being treated for diabetes, make sure you check your blood sugar level regularly and report any changes to your doctor. TOPROL-XL may change how well your diabetes is controlled. It may also cover up some of the symptoms of low blood sugar (hypoglycaemia). TOPROL-XL may increase the time your body takes to recover from low blood sugar. Your doses of diabetic medicines, including insulin, may need to change.

If you have to have any medical tests while you are taking TOPROL-XL, tell your doctor. TOPROL-XL may affect the results of some tests.

Tell any doctors, dentists, and pharmacists who are treating you that you are taking TOPROL-XL.

Things you must not do

Do not stop taking TOPROL-XL without checking with your doctor. Your doctor may want you to gradually reduce the amount of TOPROL-XL you are taking before stopping completely. This may help reduce the possibility of your condition worsening or other heart complications occurring.

Do not give TOPROL-XL to anyone else even if they have the same condition as you.

Do not use TOPROL-XL to treat any other complaints unless your doctor tells you to.

Things to be careful of

Be careful driving or operating machinery until you know how TOPROL-XL affects you. As with other beta-blocker medicines, TOPROL-XL may cause dizziness, light-headedness, tiredness, or drowsiness in some people. Make sure you know how you react to TOPROL-XL before you drive a car, operate machinery, or do anything else that could be dangerous if you are dizzy or light-headed.

Be careful drinking alcohol while you are taking TOPROL-XL. If you feel dizzy or lightheaded when you take TOPROL-XL, these conditions may get worse when you drink alcohol.

Dress warmly during cold weather, especially if you will be outside for a long time (for example when playing winter sports). TOPROL-XL, like other beta-blocker medicines, tend to decrease blood circulation in the skin, fingers and toes. It may make you more sensitive to cold weather, especially if you have circulation problems.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking TOPROL-XL.

If you get any side effects, do not stop taking TOPROL-XL without first talking to your doctor. TOPROL-XL helps most people with heart failure, but it may have unwanted side-effects in a few people.

If you are over 65 years of age you may have an increased chance of getting side effects.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:
headache, tiredness, drowsiness, weakness, or lack of energy
aches and pains, painful joints
nausea (feeling sick), vomiting,
stomach upset, diarrhoea or constipation, weight gain
dry mouth, changes in taste sensation
difficulty sleeping, nightmares
mood changes
confusion, short-term memory loss, inability to concentrate
increased sweating, runny or blocked nose
hair loss

These side effects are usually mild. Tell your doctor or pharmacist immediately if you notice any of the following:
dizziness, light headedness or fainting especially on standing up
tingling or "pins and needles"
skin rash or worsening of psoriasis
sunburn happening more quickly than usual
abnormal thinking or hallucinations
buzzing or ringing in the ears, deafness
irritated eyes or blurred vision
sexual problems

These are serious side effects. You may need urgent medical attention. Serious side effects are rare.

If any of the following happen, tell your doctor or nurse immediately:
shortness of breath, being less able to exercise
swelling of the ankles, feet or legs
chest tightness, wheezing, noisy breathing
chest pain, changes in heart rate or palpitations
swelling of the face, lips, tongue or throat which may cause difficulty in swallowing or breathing, which may be signs of a serious allergic reaction
yellowing of the skin or eyes (jaundice), generally feeling unwell
constant "flu-like" symptoms with tiredness or lack of energy

These are very serious side effects. You may need urgent medical attention or hospitalisation. These side effects are rare.

Some people may get other side effects while being given TOPROL-XL.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

After using TOPROL-XL


Keep your tablets in the blister pack until it is time to take them. If you take TOPROL-XL out of the blister pack it will not keep well.

Keep the tablets in a cool dry place where the temperature stays below 30 °C.

Do not store it or any other medicine in the bathroom or near a sink.

Do not leave it in the car or on window sills. Heat and dampness can destroy some medicines.

Keep it where young children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


Ask your pharmacist what to do with any tablets you have left over if your doctor tells you to stop taking them, or you find that the expiry date has passed.

Product description

What TOPROL-XL looks like

TOPROL-XL 23.75 tablets are white to off-white, oval, scored on both sides and marked A/Beta Symbol on one side.
TOPROL-XL 47.5 tablets are white to off-white, round, scored on one side and marked A/mO on the other side.
TOPROL-XL 95 tablets are white to off-white, round, scored on one side and marked A/mS on the other side.
TOPROL-XL 190 tablets are white to off-white, oval, scored on one side and marked A/mY on the same side.


Each TOPROL-XL tablet contains the active ingredient: Metoprolol succinate 23.75, 47.5, 95 or 190 mg, and the excipients: Ethylcellulose
Microcrystalline cellulose
Paraffin - synthetic
Macrogol 6000
Silicon dioxide
Sodium stearylfumarate
Titanium dioxide


AstraZeneca Pty Ltd
ABN 54 009 682 311
Alma Road

Australian Registration Number:

TOPROL-XL™ 23.75
Blister pack of 15 tablets
AUST R 97785

Blister pack of 30 tablets
AUST R 97786

Blister packs of 30 tablets
AUST R 97787

Blister pack of 30 tablets
AUST R 97788

TOPROL-XL™ titration pack

Composite pack containing 15 tablet blisters of each of TOPROL-XL™ 23.75, TOPROL-XL™ 47.5 and TOPROL-XL™ 95

AUST R 115007

This leaflet was prepared on 12 January 2005.

TOPROL-XL is a trade mark of the AstraZeneca group of companies
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Alternative Product(s)
There is generic brand to choose from in the table below. Generic Brands are less expensive brands that have been proven to have the same effect. Please select the desired brand.* *Some Doctor's will have "no substitution permitted" endorsed on the script. Please check your prescription as generics are not available in this case.
Metrol XL 190mg Tablets 30