Sigmaxin 250mg Tablets 100


Drug Name: digoxin
Our Price $7.39
PBS $15.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Sigmaxin 250mg Tablets 100

Sigmaxin 250mg Tablets 100

Product ID: 47083

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about SIGMAXIN.

It does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist.

All medicines have risks and benefits.

Your doctor has weighed the risks of you taking SIGMAXIN against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again.


SIGMAXIN belongs to a group of medicines known as cardiac glycosides. They work by slowing down the rate while increasing the force of your heart when it beats.

It is used to treat certain heart problems, such as:

Chronic Heart failure
Heart failure is when your heart can’t pump strongly enough to supply blood needed through out the whole body. It is not the same as a heart attack and does not mean that your heart stops.

Certain type of irregular heart beats
Irregular heart rhythms caused by an electrical problem in the upper chamber of your heart. They cause your heart to beat too fast or in an uneven way.

Your doctor may have prescribed SIGMAXIN for another reason.

Ask your doctor if you have any questions about why SIGMAXIN has been prescribed for you.

There is no evidence that SIGMAXIN is addictive.

Before you take SIGMAXIN

When you must not take it

Do not take SIGMAXIN if you have an allergy to:
digoxin or other cardiac glycosides
any of the ingredients listed at the end of this leaflet.

Symptoms of an allergic reaction to SIGMAXIN may include:
shortness of breath, wheezing or difficulty breathing
swelling of the face, lips, tongue or other parts of the body
skin rash, itching or hives

Do not take SIGMAXIN if you have or have had any of the following medical conditions:
intermittent or complete heart block or second degree atrioventricular block, (conditions where the heart misses beats) especially if there is a history of Stokes-Adams attacks.
ventricular tachycardia and ventricular fibrillation (a type of irregular heart rhythm).
irregular heart rhythm caused by cardiac glycoside overdose.
certain other irregularities of heart rhythm.

If you are not sure whether you should start taking SIGMAXIN, talk to your doctor or pharmacist.

Do not take SIGMAXIN after the expiry date (EXP) printed on the pack.

Do not take SIGMAXIN if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

Before you start to take it

Tell your doctor if you have allergies to:
any other medicines
any other substances, such as foods, preservatives or dyes

Tell your doctor if you are pregnant or intend to become pregnant. Pregnant women may require an adjustment of the dose of SIGMAXIN during pregnancy. SIGMAXIN may have harmful effects on the developing baby if the dose is too high.

Tell your doctor if you are breast-feeding or plan to breast-feed.

Tell your doctor if you have or have had any medical conditions, especially the following:
Heart disease
Heart disease caused by lack of vitamin B, known as ‘Beri-Beri disease’
Lung problems
Liver or kidney problems - effect of SIGMAXIN may be increased because of slower removal from the body
Thyroid disease - patients with low or high thyroid gland activity may be more or less sensitive to the effects of SIGMAXIN
High or Low levels of calcium, potassium in your blood
Low level of magnesium in your blood
Digestion problems

If you have not told your doctor or pharmacist about any of the above, it is important to tell them before you start taking SIGMAXIN.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

Some medicines and SIGMAXIN may interfere with each other.

These include:
amphetamine, appetite suppressants, medicines for colds, sinus problems, hay fever or other allergies – may increase the risk of heart rhythm problems
medicines for heart problems, including high blood pressure (hypertension) and irregular heart beat (arrhythmia)
diuretics (water tablets),
potassium supplements
medicines for cancer
medicines for depression
medicines for bacterial infection (antibiotics)
medicines for fungal infections (antifungals)
medicines for stomach problems, including for nausea, vomiting, diarrhoea or indigestion
some laxatives
medicines for relieving asthma attacks or other breathing problems
corticosteroids (e.g. hydrocortisone, dexamethasone, prednisolone, prednisone)
medicines for diabetes (e.g. insulin, glucagon)
cholestyramine, a medicine used for high cholesterol
phenytoin, a medicine used to control epilepsy
indomethacin – medication used for inflammation, gout or arthritis
St John’s Wort

St John’s Wort may interfere with SIGMAXIN.

These medicines may be affected by SIGMAXIN, or may affect how well it works. You may need different amounts of your medicine, or you may need to take different medicines. Your doctor will advise you.

If you not sure if any of the above apply to you, talk to your doctor or pharmacist before taking SIGMAXIN.

How to take SIGMAXIN

Follow all directions given to you by your doctor or pharmacist carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your doctor or pharmacist for help.

How much to take

Your doctor or pharmacist will tell you how much SIGMAXIN you will need to take each day. This depends on your condition and whether or not you are taking any other medicines.

How to take it

Swallow SIGMAXIN tablets with a glass of water.

After you begin taking SIGMAXIN your doctor may sometimes check its level in your blood. This will help your doctor find out if your dose needs to be changed.

Do not change your dose of SIGMAXIN unless your doctor tells you to do so.

When to take it

Take SIGMAXIN at same time each day. Taking SIGMAXIN at the same time each day will have the best effect. It will also help you remember when to take it.

It does not matter if you take SIGMAXIN before or after food.

If you forget to take it

Take it as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Do not take a double dose to make up for the dose that you missed. This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, ask your doctor or pharmacist.

How long to take it

Continue taking SIGMAXIN for as long as your doctor tells you. SIGMAXIN helps control your condition, but does not cure it. Therefore, you must take SIGMAXIN every day.

If you take too much (Overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much SIGMAXIN. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.

Symptoms of an overdose to SIGMAXIN include some of the side effects listed below.

Some early warning signs of overdose are loss of appetite, nausea, vomiting, diarrhoea, or extremely slow heart beat.

In infants and small children, the earliest signs of overdose are changes in the rate and rhythm of the heart beat.

Children may not show the other symptoms as soon as adults.

While you are using SIGMAXIN

Things you must do

Tell your doctor immediately if you notice any side effects from SIGMAXIN.

Tell any other doctors, dentists, and pharmacists who are treating you that you are taking SIGMAXIN.

You must tell your doctor, dentist, or pharmacist that you are taking SIGMAXIN before you start taking any medicines you buy from a pharmacy, health food shop or supermarket.

If you plan to have surgery that needs a general anaesthetic, tell your doctor or dentist that you are taking SIGMAXIN.

If you become pregnant while taking SIGMAXIN, tell your doctor immediately.

If you need to have any medical tests while you are taking SIGMAXIN, tell your doctor. SIGMAXIN may affect the results of some tests.

Be sure to keep all of your doctor’s appointments so that your progress can be checked. Your doctor will check your progress and may want to take some blood tests from time to time. This helps to prevent unwanted side effects.

Things you must not do

Do not give SIGMAXIN to anyone else, even if their symptoms seem similar or they have the same condition as you.

Do not take SIGMAXIN to treat any other complaints unless your doctor tells you to.

Do not stop taking SIGMAXIN, or change the dose, even if you are feeling better, without checking with your doctor.

Things to be careful of

Be careful driving or operating machinery until you know how SIGMAXIN affects you. SIGMAXIN may cause dizziness, blurred vision, and faintness in some patients. Make sure you know how you react to SIGMAXIN, before you drive a car, operate machinery, or do anything else that could be dangerous if this happens.

Side effects

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

If any of the following happen, tell your doctor or pharmacist immediately:
nausea or vomiting, loss of appetite
lower stomach pain
slow or irregular heart beats (may be fast in children)
unusual tiredness or extreme weakness
general feeling of ‘unwellness’
blurred vision or visual disturbances (e.g. coloured halos around objects ie. yellow, green, or white)
mental disturbances, such as confusion or feeling indifferent
skin rash
painful, swollen breasts, or breast enlargement in men
bleeding or bruising more easily than normal

These may be serious side effects. You may need urgent medical attention. Serious side effects are rare or are caused by a dose of SIGMAXIN that is too high for you.

Tell your doctor immediately if you have:
Chest pain
Shortness of breath or sweating

These can be symptoms of a serious heart problem caused by new irregular heart beats of a different type to those caused by atrial fibrillation (which SIGMAXIN is often used to treat). If these happen, tell your doctor immediately.

Your doctor may do regular checks on your blood levels of digoxin and body salts, as well as your kidney function to make sure SIGMAXIN is working safely for you.

This is not a complete list of side effects. Tell your doctor if you notice anything else that is making you feel unwell, even if it is not on this list.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

After taking SIGMAXIN


Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep your SIGMAXIN tablets in the pack until it is time to take them. If you take the tablets out of the pack, they will not keep well.

Store SIGMAXIN Tablets in a cool, dry place away from light and where temperature stays below 25 °C.

Do not store SIGMAXIN or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on windowsills. Heat and dampness can destroy some medicines.


If your doctor tells you to stop taking SIGMAXIN has passed its expiry date, ask your pharmacist what to do with any that is left over.

Product description

What it looks like

Tablets: (oral)
SIGMAXIN PG Tablets 62.5mcg, blue, biconvex, round tablet coded “U3A” on the upper face, bottom face plain; in bottles of 200.

SIGMAXIN Tablets 250mcg: white, biconvex, round tablet, scored and coded “X3A” on the upper face, bottom face plain; in blister packs of 100.


Active ingredient:

Other ingredients:

SIGMAXIN Tablets: lactose, maize starch, rice starch, and magnesium stearate.

SIGMAXIN PG Tablets also contain povidone and indigo carmine - Cl73015
The Australian Product Registration Numbers for:
SIGMAXIN Tablets: AUST R 90116
SIGMAXIN PG Tablets: AUST R 90114
Sigma Pharmaceuticals (Australia) Pty Ltd
96 Merrindale Drive
Croydon Victoria 3136
Telephone: (03) - 9839 2800

This leaflet was prepared in May 2002 and updated in January 2009.

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