Thioprine 50mg Tablets100


Drug Name: azathioprine
Our Price $32.69
PBS $37.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Thioprine 50mg Tablets100

Thioprine 50mg Tablets100

Product ID: 42987

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Thioprine.

It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.

All medicines have benefits and risks. Your doctor has weighed the risks of you taking Thioprine against the benefits expected for you.

If you have any concerns about taking this medicine, talk to your doctor or pharmacist.

Keep this leaflet with your medicine. You may need to read it again.

What Thioprine is used for

Thioprine is used to:
prevent rejection after organ transplants
treat autoimmune diseases, such as rheumatoid arthritis and SLE (systemic lupus erythematosus)
treat certain skin, muscle and blood disorders.

Ask your doctor if you have any questions about why Thioprine has been prescribed for you. Your doctor may have prescribed Thioprine for another reason.

Thioprine belongs to a group of medicines called immune suppressants. These medicines work by blocking the activity of some parts of the body's immune system.

Thioprine is often taken together with other medicines, such as corticosteroids.

Thioprine is available only with a doctor's prescription.

There is no evidence that Thioprine is addictive.

Before you take Thioprine

When you must not take it

Do not take Thioprine if you are allergic to:
medicines containing azathioprine (eg. Imuran, Azamun) or mercaptopurine (Puri-Nethol)
any of the ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include skin rash, itching or hives; swelling of the face, lips or tongue which may cause difficulty in swallowing or breathing; wheezing or shortness of breath.

Do not take Thioprine if:
you are pregnant, think you are pregnant or plan to become pregnant
you plan to father a child.Thioprine may harm your developing baby if you take it at the time of conception or during pregnancy.

Do not take Thioprine if you have previously taken any of the following medicines for your rheumatoid arthritis:
cyclophosphamide (eg. Cycloblastin)
chlorambucil (Leukeran)
melphalan (Alkeran).

It may not be safe for you to take Thioprine if you have taken any of the medicines in the past.

Ask your doctor if you are not sure if you have taken any of the medicines listed above in the past.

Do not take Thioprine if the expiry date (EXP.) printed on the pack has passed. If you take this medicine after the expiry date, it may not work as well.

Do not take Thioprine if the packaging shows signs of tampering or the tablets do not look quite right.

Before you start to take it

Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.

Tell your doctor if you are breastfeeding or wish to breastfeed. Taking Thioprine while breastfeeding is not recommended. Your doctor will discuss the risks and benefits of taking Thioprine when breastfeeding.

Use effective contraception to prevent pregnancy while taking Thioprine. This applies to both partners. Discuss this with your doctor.

Tell your doctor if you have any medical conditions, especially the following:
liver disease
kidney disease
myasthenia gravis
enlarged spleen
Crohn's disease or ulcerative colitis
thioprine methyltransferase (TPMT) enzyme deficiency
Lesch-Nyhan syndrome.

Tell your doctor if you have, have had or recently come in contact with anyone who has:
an infection, especially with the varicella zoster virus.

Taking Thioprine can make these infections more severe or make some people more prone to developing these infections.

Tell your doctor and dentist if you need to have any dental work done. If possible, dental work should be completed before starting Thioprine.

If you have not told your doctor about any of the above, tell them before you start taking Thioprine.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop. Some medicines may be affected by Thioprine, or may affect how well it works. These include:
other immune suppressants, such as tacrolimus (Prograf) or cyclosporin (eg. Neoral, Sandimmun), D-penicillamine (D-Penamine)
allopurinol (eg. Zyloprim, Progout), a medicine used to treat gout
medicines used to treat cancer
captopril (eg. Capoten, Acenorm), a medicine used to treat high blood pressure and certain heart conditions
warfarin (Coumadin, Marevan), a medicine used to prevent blood clots
vaccines or immunisations
phenytoin (Dilantin) and phenobarbitone, medicines used to treat epilepsy or fits
cimetidine (eg. Tagamet, Magicul), a medicine used to treat reflux and ulcers
indomethacin (Indocid, Arthrexin), a medicine used to relieve pain, swelling and other symptoms of inflammation, including arthritis
rifampicin (Rifadin, Rimycin) and erythromycin (eg. EES, E-Mycin), antibiotics used to treat infections
aminosalicylates, medicines used to treat bowel disorders such as Crohn's disease and ulcerative colitis, e.g., mesalazine (eg. Mesasal), olsalazine (Dipentum), sulfasalazine (eg. Salazopyrin).

Your doctor can tell you what to do if you are taking any of these medicines.

If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist. Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Thioprine.

How to take Thioprine

Follow all directions given to you by your doctor and pharmacist carefully. They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your doctor or pharmacist.

How much to take

Your doctor will tell you how many tablets you need to take each day and when to take them. This depends on your condition, your body weight and whether or not you are taking any other medicines.

How to take Thioprine

Swallow the tablets whole with a glass of water.

Do not break, crush or chew the tablets.

When to take Thioprine

Take Thioprine with or immediately after food. This will reduce the chance of a stomach upset.

Take your medicine at about the same time each day. Taking it at the same time each day will have the best effect. It will also help you remember when to take it.

How long to take Thioprine for

Keep taking Thioprine for as long as your doctor recommends. The length of time you are treated with Thioprine will depend on your condition. For those who have had transplants, use of Thioprine is usually long-term.

If you forget to take Thioprine

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets as you would normally.

Do not take a double dose to make up for the dose you missed.

If you are not sure what to do, ask your doctor or pharmacist.

If you take too much Thioprine (overdose)

Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26), if you think you or anyone else may have taken too much Thioprine. Do this even if there are no signs of discomfort or poisoning.

While you are taking Thioprine

Things you must do

Before starting any new medicine, tell your doctor or pharmacist that you are taking Thioprine.

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Thioprine.

If you become pregnant while taking Thioprine, tell your doctor immediately.

Visit your doctor regularly so that they can check on your progress. You will need to have blood tests every week during the first eight weeks of treatment, and then once a month, while you are taking Thioprine.

If outdoors, wear protective clothing and use a 30+ sunscreen to protect yourself from the effects of the sun. There have been reports of skin cancer occurring in transplant patients taking Thioprine.

Tell your doctor if you develop lumps anywhere in your body. Also, tell your doctor if you develop any new moles or notice changes in existing moles. These changes may be early signs of cancer. Immune suppressant medicines, including Thioprine, may increase the risk of developing certain types of cancer, including skin cancer and lymphoma (cancer of the lymphatic system). Talk to your doctor if you are concerned about this.

If you need to have surgery, tell your anaesthetist, surgeon or doctor or that you are taking Thioprine.

Since Thioprine is meant to be taken regularly every day, keep a continuous supply of medicine so you don't run out, especially over weekends or holidays.

Things you must not do

Do not have any vaccinations or immunisations without first checking with your doctor. Thioprine lowers your body's resistance to infection. You may develop the infection the vaccination/immunisation is meant to prevent.

Do not stop taking Thioprine, or lower the dose, without checking with your doctor. Your doctor may want you to gradually reduce the amount of Thioprine you are taking before stopping completely.

Do not use Thioprine to treat any other conditions unless your doctor tells you to.

Do not give Thioprine to anyone else, even if they have the same condition as you.

Things to be careful of

If you are taking Thioprine after a transplant, avoid contact with people who have infections. Do not touch your eyes or the inside of your nose unless you have just washed your hands. Due to the immune suppressant effects of Thioprine, you have an increased risk of getting infections after a transplant.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Thioprine. Like all other medicines, Thioprine may have unwanted side effects in some people. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following mild side effects and they worry you:
nausea, vomiting, diarrhoea
hair loss (usually reversible)
skin rash, redness
sensation of ants crawling over the skin
aching, tender or weak muscles, not caused by exercise
changes in taste and smell.

Tell your doctor immediately if you notice any of the following serious side effects:
coughing, wheezing or difficulty breathing
signs of infection such as fever, chills, sore throat or mouth ulcers
tiredness, being short of breath when exercising, dizziness and looking pale
bruising or bleeding more easily than normal, purplish-blue spots under the skin
bloody or black tarry stools
diarrhoea, usually with blood and mucus, stomach pain and fever
passing little or no urine, together with drowsiness, nausea and vomiting
severe upper stomach pain, often with nausea and vomiting
yellowing of the eyes or skin
fever, headache, vomiting, stiff neck and sensitivity to bright light
irregular heart beat
severe skin condition with blisters and bleeding in the lips, eyes, mouth, nose and genitals.

The above side effects require medical attention or even hospitalisation.

Tell your doctor if you notice anything that is making you feel unwell while you are taking, or soon after you finish taking, Thioprine. Other side effects not listed above may also occur in some people.

After taking Thioprine


Keep Thioprine where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep your tablets in the pack until it is time to take them. If you take the tablets out of the pack they may not keep well.

Keep your tablets in a cool dry place where the temperature stays below 30 °C.

Do not store Thioprine or any other medicine in the bathroom or near a sink.

Do not leave Thioprine in the car or on window sills. Heat and dampness can destroy some medicines.


If your doctor tells you to stop taking Thioprine, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

There are two Thioprine tablets available at present:
a round, yellow, film-coated tablet, scored and marked "GX" above the score and "CH1" below the score on one side and blank on the reverse
a round, yellow, film-coated tablet, scored and marked "AZA" above the score and "50" below the score on one side and blank on the reverse.

The tablets marked "GX" over "CH1" are replacing the tablets marked "AZA" over "50".

Each pack contains 100 tablets.


The active ingredient in Thioprine is azathioprine. Each Thioprine tablet contains 50 mg of azathioprine.

The tablets also contain the following inactive ingredients:
maize starch
pregelatinised maize starch
stearic acid
magnesium stearate
macrogol 400.

The tablets are gluten free.


Thioprine is supplied by:
Alphapharm Pty Limited
(ABN 002 359 739)
Chase Building 2
Wentworth Park Road
Glebe NSW 2037
Phone: (02) 9298 3999
Medical Information
Phone: 1800 028 365

Australian registration number:
AUST R 57002.

This leaflet was prepared on

17 November 2006.
Preferred Generic
Our preferred generic for this medication is listed below. A generic prescription medicine works in the same way as the existing medicine. What matters is the active ingredient, which is the same in the generic brands and the existing brand. Please click on it below to view the product(s).
Azathioprine Sandoz 50mg Tablets 100
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Alternative Product(s)
There is generic brand to choose from in the table below. Generic Brands are less expensive brands that have been proven to have the same effect. Please select the desired brand.* *Some Doctor's will have "no substitution permitted" endorsed on the script. Please check your prescription as generics are not available in this case.
Azathioprine Sandoz 50mg Tablets 100
Imuran 50mg Tablets 100