Parnate 10mg Tablets 200 (4 x 50) (Authority Script)


Drug Name: tranylcypromine
Our Price $0.00
PBS $37.30
Concession $5.20
Safety Net $0.00

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Parnate 10mg Tablets 200 (4 x 50) (Authority Script)

Parnate 10mg Tablets 200 (4 x 50) (Authority Script)

Product ID: 41152

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

This leaflet answers some of the common questions about PARNATE. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. Please read this leaflet before you start taking PARNATE. If you are helping someone else take PARNATE, please read this leaflet before you give the first dose.

All medicines have risks and benefits. Your doctor has weighed the possible risks of taking PARNATE against the expected benefits. Keep this leaflet with the medicine. You may want to read it again.

The name of your medicine is PARNATE also known as tranylcypromine.

There are many different types of medicines used to treat depression. PARNATE belongs to a group of medicines called monoamine oxidase inhibitor (MAOI) antidepressants.

Depression is longer lasting or more severe than the 'low moods' that every one has from time to time. It is thought to be caused by a chemical imbalance in parts of the brain. The imbalance affects your whole body and can cause emotional and physical symptoms. You may feel low in spirit, lose interest in usual activities, be unable to enjoy life, have poor appetite or overeat, have disturbed sleep, often waking up early, low energy and feel guilty over nothing. PARNATE corrects the chemical imbalance and so helps relieve the symptoms of depression. Your doctor may have prescribed PARNATE for another use. Ask your doctor if you have questions about why PARNATE has been prescribed for you.


You are allergic to PARNATE, any MAOI type medicine or any of the ingredients listed in the ingredient section of this leaflet. Signs of allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue.
If you have taken PARNATE or any other MAOI medication (e.g. Nardil, Aurorix) before and became unwell, tell your doctor or pharmacist before taking the first dose.
You are taking any other medications for the treatment of depression or anxiety or have done so in the last 1 to 2 weeks.
You are over 60 years of age unless instructed to by your doctor.
You have any of these medical conditions:
- A history of stroke or poor blood flow to the brain
- Liver disease
- Blood or bone marrow disorder
- Pheochromocytoma (an adrenaline producing tumour of the adrenal gland)
You are already taking any of the following medicines:
- Appetite suppressants fenfluramine (Ponderax Pacaps), dextenflouramine (Adifax) phenteramine(Duromine), mazindol (Sanorex) or diethyl proprion (Tenuate, Tenuate Dospan) for weight loss
- Cold or hay fever medicines (including nose drops or sprays)
- Cough suppressants e.g. Dextromethorphan
- Blood pressure medicines
- Strong pain killers eg Pethidine, Codeine
- Levodopa (Madopar or Sinemet) for Parkinsons disease
- Tryptophan
The expiry date (EXP) printed on the pack has passed
The packaging is torn or shows signs of tempering
Do not give Parnate to children and adolescents under 18 years of age. The safety of Parnate in this age group has not been established.

Do not give this medicine to anyone else. Your doctor has prescribed it specifically for you and your condition

You have had an allergic reaction to any medicine which you have taken previously to treat your current condition.
You are pregnant or intend to become pregnant. Your doctor will discuss with you the possible risks and benefits of using PARNATE during breastfeeding.
You have any of these medical conditions:
- Diabetes
- Epilepsy
- Overactive thyroid gland
- Angina or other heart problems
- Kidney problems
- You are planning to have any type of surgery
Tell your doctor if you are taking any other medicines or have used other medicines until recently. This includes those that you buy without a prescription. In particular tell your doctor if you are taking any of the following medicines:

Medicines used for the treatment of depression or anxiety
Blood thinning medication eg warfarin (Marevan, Coumadin) or heparin
Appetite suppressants eg fenfluramine (Ponderax Pacaps), dextenflouramine (Adifax) phenteramine(Duromine), mazindol (Sanorex) or diethyl proprion (Tenuate, Tenuate Dospan) for weight loss
Cold or hay fever medicines (including nose drops or sprays)
Cough suppressants e.g. Dextromethorphan
Blood pressure medicines
Strong pain killers eg Pethidine, Codeine
Barbiturates eg amylobarbitone (Amytal, Neur-Amyl), butobarbitone (Soneryl), mrthylphenobarbitone (Prominal), pentobarbitone, phenobarbitone
Levodopa (Madopar or Sinemet) for Parkinsons disease
Some medicines may affect the way other medicines work. Your doctor or pharmacist will be able to tell you which medicines are safe to take with PARNATE.

Follow your doctor's instructions about how and when to take PARNATE.

Read the directions carefully, if you have any concerns about how to take PARNATE, talk to your doctor or pharmacist.

The usual dose of PARNATE is one 10 mg tablet taken twice a day.

Swallow PARNATE tablet(s) whole with a full glass of water or another liquid. Do not chew the tablets. PARNATE may be taken with or without food.

PARNATE tablets are usually taken in the morning and at midday. Take the last dose of the day not later than 3 pm. This will help avoid sleep disturbances.

For depression, the length of treatment will depend on how quickly your symptoms improve. Most antidepressants take time to work , so do not be discouraged if you do not feel better right away. Some of your symptoms may improve in 1 or 2 weeks but it can take up to 4 or 6 weeks to feel any real improvement. Even when you feel well, you will usually have to take PARNATE for several months or even longer to make sure the benefits will last. Continue taking PARNATE until the doctor tells you to stop.

Do not take an extra dose. Wait until the next dose and take your normal dose then.

Do not try to make up for the dose that you missed by taking more than one dose at a time.

Immediately telephone your doctor or Poisons Information Centre (telephone in Australia-13 11 26; telephone in New Zealand - 0800 POISON or 0800 764 766) for advice or go to the Emergency Department at your nearest hospital, if you think that you or any one else may have taken too much PARNATE. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

The most important reaction associated with PARNATE overdose is the occurrence of hypertensive crises, which are characterised by some or all of the following symptoms:

Back head headache which may radiate frontally, palpitation, neck stiffness or soreness, nausea or vomiting, sweating with early pallor followed later by flushing. Either rapid heart beat or slow heartbeat may be present; and associated dilation of pupils may also occur. This headache, together with pain and stiffness in the cervical muscles, may mimic subarachnoid haemorrhage, but can equally be associated with actual intracranial bleeding, as in other conditions where a sudden rise in blood pressure occurs. Cases of such bleeding have been reported, some of which have been fatal.

Depression, stupor or coma may also be present or develop. Blood pressure may be raised, but hypotension may occur.

Certain foods and drinks must be avoided during treatment with PARNATE and for two weeks after ceasing therapy. PARNATE reacts with a chemical found in a variety of foods. This reaction may cause sudden high blood pressure which may be experienced as severe headache, nausea, vomiting or rapid heartbeat. Avoid protein foods that have been aged or fermented to improve flavour. Avoid any foods that have caused you unpleasant reactions previously. Food and drink to be avoided while taking PARNATE include:
- Matured cheese
- Meat, fish, poultry, pate or yoghurt that are stale or smell "off"
- Protein extracts such as Marmite, Vegemite, Bonox, Bovril, Promoite
- Pods of broad beans, sauerkraut
- Smoked or pickled fish
- Sour cream
- Soy bean products eg soy sauce, miso, tofu
- Avocado
- Yeast extracts
- Banana skins
- Red wines such as chianti
- Home brewed beers or liqueurs
Check with your doctor, pharmacist or dentist before taking any other medicines. This applies to medicines that you buy without a prescription as well as prescribed medicines.

Watch carefully for signs that your depression or anxiety is getting worse, especially in the first few weeks of treatment.

Tell your doctor immediately if you experience any of the following symptoms, especially if they are severe, you have not had these symptoms before or they happen very suddenly:

Anxiety or agitation
Panic attacks
Difficulty sleeping
Hostility or impulsiveness
Overactivity or uninhibited behaviour
Thoughts of suicide
Tell your doctor immediately if you have any thoughts about suicide or doing harm to yourself.

Warning signs of suicide:
All thoughts or talk about suicide or violence are serious. If you or someone you know is showing the following warning signs, either contact your doctor or a mental health advisor right away or go to the nearest hospital for treatment:

Thoughts or talk about death or suicide
Thoughts or talk about self-harm or doing harm to others
Any recent attempts of self-harm
An increase in aggressive behaviour, irritability or agitation
Be careful driving or operating machinery until you know how PARNATE affects you. PARNATE may cause drowsiness, dizziness or light-headedness in some people. Make sure you know how you react to PARNATE before you drive a car or operate machinery. Avoid large amounts of caffeine-containing foods or drinks such as chocolate, coffee, tea or cola. These may trigger off a migraine-like headache in some people taking PARNATE.

When your doctor decides that you should stop taking PARNATE they may decide to reduce your dose or the interval of your dose over 1 to 2 weeks. Some people may suffer symptoms such as dizziness or anxiety if PARNATE is stopped suddenly. Avoid or reduce the amount of alcohol you drink. Do not drink more than two of the allowed standard alcoholic drinks (spirits, white wine or commercial beers). Alcohol may make you more sleepy, dizzy and light-headed than usual.

After you stop taking PARNATE you must continue to follow the restrictions regarding food, alcohol and other medications for two weeks.

Before you have any surgery or emergency treatment, tell your doctor or dentist that you are taking PARNATE or have used it in the last two weeks. Carry an alert card or wear an SOS bracelet, which tells the doctor you are taking PARNATE. These are helpful if you are in an accident and cannot talk.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking PARNATE. Like other medicines, PARNATE can cause some side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Tell your doctor if you notice any of the following that are troublesome or ongoing:
- rash
- mild dizziness on standing, drowsiness, weakness, fatigue, difficulty sleeping, tremors, nervousness, blurred vision
- dry mouth, nausea, constipation, vomiting
- stomach pain, diarrhoea, loss of appetite
- ringing in the ears, chills
- swelling in ankles or limbs, weight gain, excess sweating
- sexual problems.
Tell your doctor immediately if you notice any of the following:
- severe dizziness or fainting on standing
- fast heart beat
- unusual bleeding or bruising
- yellowing of the skin and eyes (jaundice)
- agitation, confusion or nervousness
- muscle spasms or twitches
- difficulty passing urine.
Stop taking PARNATE and contact your doctor or go to the emergency department of your nearest hospital if any of the following happens:
- allergic reaction including fainting, swelling of limbs, face, lips, mouth or throat which may cause difficulty swallowing or breathing
- severe or frequent headaches, chest pain, fast or slow heart beat, neck stiffness or soreness, sweating with initial paleness followed by flushing of the skin, enlarged pupils, nausea and vomiting.
Other rare side effects that have been reported include disorders of the liver and blood.

This is not a complete list of all possible events reported. Other events may occur in some people and there may be some unwanted effects not yet known. Remember to tell your doctor as soon as possible if you do not feel well when you are taking or soon after you have stopped taking PARNATE.

Keep your tablets in the blister pack until it is time to take them. Keep the pack in a cool dry place at or below 25°C. Do not leave it in the car on a hot day. Do not store medicine in the bathroom or near a sink. Heat and dampness can destroy some medicines.

Store all medicines out of the reach of children such as in a locked cupboard.

If your doctor tells you to stop taking PARNATE, ask your pharmacist what to do with any tablets that are left over.

PARNATE comes as a red, round, film-coated tablet containing 10 mg of tranylcypromine.


PARNATE tablets also contain inactive ingredients including calcium sulfate, starch maize, sucrose, magnesium stearate, gelatin, erythrosine (red, 127), iron oxide yellow (yellow, 172), cochineal (red, 120), iron oxide red (red, 172), iron oxide black (black, 172), talc, carnauba wax, hypromellose and propylene glycol.

PARNATE tablets do not contain lactose, gluten or tartrazine

PARNATE tablets are only available if prescribed by a doctor. PARNATE comes in packs of 50 tablets (AUST R 60821).

Distributed in Australia by:

LINK Medical Products Pty Ltd
Level 1 Bridgepoint Centre
3 Brady Street
Mosman NSW 2088, Australia

Distributed in New Zealand by:

LINK Pharmaceutical Pty Ltd.
Level 20 ASB Bank Centre
135 Albert Street
Auckland, New Zealand

Date of Leaflet Preparation:
July 7, 2000

Date of Last Update:
December 22, 2004
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