Karvezide 300/12.5mg Tablets 30


Drug Name: irbesartan + hydrochlorothiazide
Our Price $11.50
PBS $17.80
Concession $7.11
Safety Net $1.91

S8 Note - This prescription item is Schedule 8 and can only be supplied on a script from a registered doctor in Queensland. Any prescriptions from any other state cannot be filled and will be returned in the mail

Note: Private, PBS and our prices are available to the general public. Concession and Safety Net prices are only available to people with the appropriate concession or Safety Net cards. See Prescriptions for more details.


This prescription item requires a pre approved authority from the Government in order to get this item at the quoted price. Authority prescriptions need to be applied for by the doctor writing the script and can include reasons such as increased quantities due to dosage, increased repeats, use for a pre determined specified use, or the nature of the medication itself requiring specialist interaction. In the event that an authority is not granted on the script, the price will revert to the private price quoted for that item


This item contains more than one pack of a prescription product. Before this can be dispensed the doctor has to give approval. The prescription must be written for the total quantity or the prescription must be endorsed by your doctor "Regulation 24" otherwise we will be unable to dispense the increased amount. If you proceed with the order without approval, we will only send out one pack at the single pack price and refund the difference. Eg If your prescription is written out for 30 Tablets with 5 repeats and it does not have “Regulation 24 “ written on the script, the ONLY quantity we can dispense is 30 at one time. Further dispensing of this product could only occur after an appropriate length of time - usually 21 days but depends on dosage. In this example if you would like to obtain 180 Tablets then the doctor must endorse the prescription “Regulation 24” or the quantity must be written out for 180 and not 30. NB Conditions apply on the writing of a Regulation 24 prescription. Ask your doctor or pharmacist for details.

We can no longer accept signed authority forms from your doctor as permission to dispense more than one pack. Please contact our pharmacist for more information.

If you order this item as Private, NO PBS stickers will be issued. Once any prescription order has been sent the product cannot be returned for a refund even if your doctor changes your medication or you have an adverse reaction.

Karvezide 300/12.5mg Tablets 30

Karvezide 300/12.5mg Tablets 30

Product ID: 39534

Pharmacist Only Medicine

This product is a Pharmacist Only Medicine and requires pharmacist advice before we can dispatch this product. You must first place the order and then contact our pharmacists within 48 hours on 1300 367 283. The pharmacist will determine if this product is appropriate for you and if so, approve the order. In the event that you do not do this, the product will be deleted from your order and the balance of your order will be dispatched. This is not required if you have a doctor's prescription.


General Information

Consumer Medicine Information

What is in this leafletThis leaflet answers some common questions about Karvezide. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.All medicines have benefits and risks. Your doctor has weighed the benefits of you taking this medicine against the risks it will have for you.If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with your medicine. You may need to read it again.

What Karvezide is used forKarvezide is used to lower high blood pressure, which doctors call hypertension.Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) when your blood pressure stays higher than is needed, even when you are calm and relaxed.There are often no symptoms of high blood pressure. The only way of knowing that you have high blood pressure is to have your blood pressure checked on a regular basis.If high blood pressure is not treatedit can lead to serious health problems, such as stroke, heart disease and kidney failure.How Karvezide works

Karvezide contains irbesartan and hydrochlorothiazide. Bothmedicines reduce blood pressure in different ways. Irbesartan belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body that causes blood vessels to narrow. Irbesartan blocks angiotensin-II and therefore widens your blood vessels, making it easier for your heart to pump blood throughout your body. This helps to lower your blood pressure.Hydrochlorothiazide belongs to the class of medicines known as diuretics. Diuretics cause an increase in the volume of urine. They also help with lowering blood pressure particularly when combined with other blood pressure reducing medicines.Your doctor may have prescribed Karvezide for another reason. Ask your doctor if you have any questions about why Karvezide has been prescribed for you.This medicine is only available with a doctor's prescription.There is no evidence that this medicine is addictive.Before you take KarvezideWhen you must not take it

Do not take Karvezide if:
you are pregnant (or think you may be pregnant) or are planning to become pregnant.

Karvezide may affect your developing baby if you take it during pregnancy.
you are breast-feeding or are planning to breast-feed.
you are allergic to irbesartanor hydrochlorothiazide or to sulfonamide derived medicines (commonly known as sulfur drugs), or to any of the ingredients listed under at the end of this leaflet.
you are not producing urine.
the packaging is torn or shows signs of tampering.
the expiry date on the pack has passed.

If you take this medicine after the expiry date has passed, it may not work.If you are not sure if you should start taking Karvezide, talk to your doctor.

Karvezide should not be given to children.

Before you start to take it

Tell you doctor if have any allergies to:
any of the ingredients listed at the end of this leaflet including lactose
any other medicines, including sulfonamide derived medicines (commonly known as sulfur drugs)
any other substances , such as foods, preservatives or dyes

Tell your doctor if you are pregnant or intend to become pregnant.

Tell your doctor if you are breast-feeding or plan to breastfeed.

Tell your doctor if you have or have had any medical conditions, especially the following:
recent excessive vomiting or diarrhoea or think you are dehydrated
kidney problems, or have had a kidney transplant or dialysis
heart problems
liver problems, or have had liver problems in the past
gout or have had gout in the past
lupus erythematosus
high or low levels of potassium or sodium or other electrolytes in your blood
primary aldosteronism
you are strictly restricting your salt intake
you have had a sympathectomy
You have been taking diuretics
You have a history of allergy or asthma

Tell your doctor if you plan to have surgery (even at the dentist) that needs a general anaesthetic.

If you have not told your doctor about any of the above, tell them before you take Karvezide.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from your pharmacy, supermarket or health food shop.

It is especially important that you tell your doctor if you are taking or plan to take any of the following:
other medicines for high blood pressure
other fluid tablets or diuretics
lithium or lithium-containing medicines (for exampleLithicarb)
potassium tablets (for example Span-K, Slow-K, Mag-K)
potassium-containing salt substitutes (for examplePressor-K)
anti-inflammatory medicines (these are used to relieve pain, swelling and other symptoms of inflammation, including arthritis) and include nonsteroidalanti-inflammatory agents - NSAIDs (for example Voltaren, Indocid) and COX- 2 inhibitors (for example Celebrex). Taking a combination of Karvezide and an anti-inflammatory medicine may damage your kidneys.
alcoholic drinks
sleeping tablets
strong pain killing medicines such as codeine or morphine
medicines for diabetes (oral tablets or capsules or insulins)
calcium supplements or medicines containing calcium
Vitamin D
medicines for gout.
powder or granules used to help reduce cholesterol (Questran Lite or Colestid Granules)
heart medicines such as digoxin or antiarrhythmic medicines (for example Sotacor)
corticosteroid medicines such as prednisone, cortisone or ACTH
medicines used to treat cancer (cytotoxic medicines)
amantadine (Symmetrel), a medicine used to treatParkinson's disease or to prevent influenza
anticholinergic medicines, these can be used to treat Parkinson's disease, to relieve stomach cramps or spasms or used to prevent travel sickness
medicines used during surgery
medicines used in an emergency situation such as adrenaline

Your doctor will decide whetheryour treatment needs to be altered or whether you should have check ups more frequently.Your doctor and pharmacist may have more information on medicines to be careful with or avoid while taking Karvezide.How to take KarvezideHow much to take:

Karvezide will usually be prescribed by your doctor if previous treatment does not produce a sufficient drop in your blood pressure. Your doctorwill tell you how to switch from your previous treatment to Karvezide.The usual dose of Karvezide is one tablet a day. The full blood pressure lowering effect should be reached 6-8 weeks after beginning treatment. If your blood pressure is not satisfactorily reduced with Karvezide, your doctor may prescribe another medicine to be taken with Karvezide.How to take it

Swallow the tablet whole with a glass of water.

It does not matter whether you take Karvezide tablets before or after food.When to take it

Take Karvezide at about the same time each day. Taking your tablets at the same time each day will have the best effect. It will also help you remember when to take the tablets.

How long to take it

Continue taking Karvezide until your doctor tells you to stop. Karvezide helps control your high blood pressure but does not cure it. Therefore Karvezide must be taken every day.

To help you remember to take your tablets each day, Karvezide tablets are supplied in a Calendar pack with the foil backing marked with thedays of the week. This is just a way to help you to remember to take your tablets. All of the tablets in the pack are the same.When you start a new strip of tablets, take the tablet marked "START". On the next day, take the tablet marked with the relevant day of the week.

Continue taking your tablets each day until all of the tablets are taken. Commence the next strip at "START" and continue as before.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Otherwise, take it as soon as you remember, and go back to taking your tablets as you would normally.

Do not take a double dose to make up for the dose you missed. This may increase the chance of you getting any unwanted side effects.

If you have trouble remembering to take your tablets, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone: 13 11 26) or go to Accident and Emergency at your nearest hospital, if you think that you or anyone else may have taken too much Karvezide.

Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.

If you take too many Karvezide tablets, you will probably feel lightheaded or dizzy.While you are using KarvezideThings you must do

Tell any other doctors, dentists and pharmacists who are treating you that you are taking Karvezide.

If you become pregnant while taking Karvezide tell your doctor immediately.

Have your blood pressure checked when your doctor tells you to, to make sure Karvezide is working.

If you are about to be started on any new medicine, tell your doctor and pharmacist that you are taking Karvezide.

If you plan to have surgery or other treatment (even at the dentist) that needs an anaesthetic, make sure that you tell your doctor or dentist that you are taking Karvezide. Your blood pressure may drop suddenly.

Make sure you drink enough water during exercise and hot weather when you are taking Karvezide, especially if you sweat a lot. If you do not drink enough water while taking Karvezide, you may faint or feel light-headed or sick. This is because your body does not have enough fluid and your blood pressure is low. If you continue to feel unwell, tell your doctor.

If you have excessive vomiting and/or diarrhoea while taking Karvezide, tell your doctor. You may loose too much water and salt and your blood pressure may drop too much.

If you feel light headed or dizzy after taking your first dose of Karvezide, or when your dose is increased, tell your doctor immediately.

Things you must not do

Do not give Karvezide tablets to anyone else, even if they have the same condition as you.

Do not take Karvezide to treat any other complaints unless your doctor or pharmacist tells you to.

Do not stop taking Karvezide, or lower the dosage, without checking with your doctor.

Things to be careful of

If you feel light-headed, dizzy or faint when getting out of bed or standing up, get up slowly.

Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this problem continues or gets worse, talk to your doctor.

Be careful driving or operating machinery until you know how Karvezide affects you. As with many other medicines used to treat high blood pressure, Karvezide may cause dizziness or light-headedness in some people. If this occurs do not drive. Make sure you know how you react to Karvezide before you drive a car, operate machinery or do anything else that could be dangerous if you are dizzy or light-headed.

If you drink alcohol, dizziness or light-headedness may be worse.The hydrochlorothiazide contained in this medicine could produce a positive analytical result in an antidoping test.Things that would be helpful for lowering your blood pressure

Some self help measures suggested below may help your condition. Talk to your doctor or pharmacist about these measures and for more information.Alcohol -
your doctor may advise you to limit your alcohol intake

Weight -
if you are overweight, your doctor may suggest losing some weight to help lower your blood pressure and help lessen the amount of work your heart has to do. Some people may need a dietician's help to lose weight.

Diet -
your doctor may advise you toeat a healthy low-fat diet which includes plenty of fresh vegetables, fruit, bread, cereals and fish.

Salt -
your doctor may advise you to watch the amount of salt in your diet. To reduce your salt intake you should avoid using salt in cooking or at the table.

Exercise -
regular exercise helps to reduce blood pressure and helps get the heart fitter, but it is important not to overdo it. Walking is good exercise, but try to find a route that is reasonably flat. Before starting any exercise, ask your doctor about the best kind of programme for you.

Smoking -
your doctor may advise you to stop smoking or at least cut down.

Side effectsTell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Karvezide. Karvezide helps most people with high blood pressure, but it may have unwanted side effects in a few people. All medicines can have side effects. Sometimes they are serious.

Most of the time they are not. You may need medical treatment if you get some of the side effects.Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:
dizziness or light-headedness
unusual tiredness or weakness, fatigue
pain in the stomach or gut nausea and/or vomiting
sexual problems

These are generally mild and do not normally require treatment to be interrupted.Tell your doctor immediately if you notice any of the following:
skin rash or itchiness
aching muscles or sore joints, not caused by exercise
muscle pain or weakness
buzzing, ringing or other persistent noise in the ears
changes in heart rhythm
you are not urinating (passing water) as much as normal
numbness or tingling in fingers or toes
painful, swollen joints that may be symptoms of gout
yellowing of the skin and/or eyes, also known as jaundice
symptoms that may occur if you have developed diabetes, such as excessive thirst, passing greatly increased amounts of urine, increased appetite with weight loss, feeling tired, drowsy, weak, depressed, irritable and generally unwell
symptoms that may indicate kidney disease such as passing little or no urine, drowsiness, nausea, vomiting, breathlessness, loss of appetite and weakness
symptoms that may indicate high potassium levels in the blood
such as nausea, diarrhoea, muscle weakness and changes in heart rhythm.
symptoms that may indicate liver disease such as nausea, vomiting, loss of appetite, feeling generally unwell, fever, itching, yellowing of the skin and eyes and dark coloured urine.

These are serious side effects. Skin rash and itchiness may be symptoms of an allergic reaction.You may need medical attention. These side effects are not common.If any of the following happen, stop taking Karvezide and either tell your doctor immediately or go to Accident and Emergency at your nearest hospital:
swelling to the face, lips, tongue or throat, which may cause difficulty in swallowing or breathing.
severe and a sudden onset of pinkish, itchy swellings on the skin, also called hives or nettlerash.

These are very serious side effects. You may need urgent medical attention or hospitalisation.These side effects are very rare.Other side effects not listed above may occur in some patients. Tell your doctor or pharmacist if you notice anything that is making you feel unwell.

After using KarvezideStorage

Keep your Karvezide tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they will not keep well.

Keep Karvezide tablets in a cool dry place where the temperature stays below 25 degrees C. Do not store Karvezide or any other medicine in the bathroom near a sink. Do not leave them near a radiator, in a car on a hot day or on a window sill. Heat and dampness can destroy some medicines.

Keep all medicines out of the reach of children. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If your doctor tells you to stop taking Karvezide or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets that are left over.

Product descriptionWhat it looks like

Karvezide 150/12.5 tablets - peach, oval, film-coated tablet with a heart shape on one side and "2875" on the other. Pack size: 30 tablets. AUST R 101831.Karvezide 300/12.5 tablets - peach, oval, film-coated tablet with a heart shape on one side and "2876" on the other. Pack size: 30 tablets. AUST R 101833.Karvezide 300/25 tablets - pink, oval, film-coated tablet with a heart shape on one side and "2788" on the other. Pack size: 30 tablets. AUST R 129442.Active Ingredients

Karvezide 150/12.5 tablets - 150 mg Irbesartan and 12.5 mg Hydrochlorothiazide per tablet.Karvezide 300/12.5 tablets - 300 mg Irbesartan and 12.5 mg Hydrochlorothiazide per tablet.Karvezide 300/25 tablets - 300 mg Irbesartan and 25 mg Hydrochlorothiazide per tablet.Other Ingredients

Karvezide 150/12.5 & 300/12.5 tablets also contain carnauba wax, croscarmellose sodium, hypromellose, lactose, iron oxide red CI 77491, iron oxide yellow CI 77492, macrogol 3000, magnesium stearate, microcrystalline cellulose, silicon dioxide, and titanium dioxide.Karvezide 300/25 tablets also contain carnauba wax, croscarmellose sodium, hypromellose, lactose, iron oxide red CI 77491, iron oxide yellow CI 77492, iron oxide black CI 77499, macrogol 3350, magnesium stearate, microcrystalline cellulose, silicon dioxide, pregelatinised maize starch, and titanium dioxide.Supplier

Karvezide is supplied in Australia by:
sanofi-aventis australia pty ltd
12-24 Talavera Road
Macquarie Park, NSW 2113.

Karvezide is a registered sanofi-aventis trademark.This leaflet was prepared in October 2008.
Preferred Generic
Our preferred generic for this medication is listed below. A generic prescription medicine works in the same way as the existing medicine. What matters is the active ingredient, which is the same in the generic brands and the existing brand. Please click on it below to view the product(s).
Irbesartan/HCT Sandoz 300mg/12.5mg Tablets 30
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Alternative Product(s)
There is generic brand to choose from in the table below. Generic Brands are less expensive brands that have been proven to have the same effect. Please select the desired brand.* *Some Doctor's will have "no substitution permitted" endorsed on the script. Please check your prescription as generics are not available in this case.
Avapro HCT 300/12.5mg Tablets 30
Irbesartan HCTZ Ranbaxy 300mg/12.5mg Tablets 30
Irbesartan/HCT Sandoz 300mg/12.5mg Tablets 30
Karvezide 300mg/12.5mg Tablets 60 Authority Script
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